Manganese and Compounds Reference Exposure Levels
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چکیده
Acute inhalation of high levels of manganese results in a nonspecific pulmonary edema, while chronic manganese inhalation leads to a characteristic neurotoxicity known as manganism with strong similarities to Parkinson’s disease. Manganism is characterized by motor deficits (dystonia, altered gait, fine tremor, generalized rigidity) and may include psychiatric disturbances. At low manganese levels and in the absence of frank manganism, subtle deficits in cognitive and neurobehavioral functions have been reported in both adults and children. Neurodevelopmental deficits have been associated with early life exposure to excessive manganese and include impaired intellectual performance and behavioral disinhibition. The studies described in this document include those published through the Spring of 2008. The RELs below are applicable to all respirable inorganic manganese compounds.
منابع مشابه
Manganese and Compounds Reference Exposure Levels
Acute inhalation of high levels of manganese results in a nonspecific pulmonary edema, while chronic manganese inhalation leads to a characteristic neurotoxicity known as manganism with strong similarities to Parkinson’s disease. Manganism is characterized by motor deficits (dystonia, altered gait, fine tremor, generalized rigidity) and may include psychiatric disturbances. At low manganese lev...
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